Shomurodova D.S., Igamova S.S., Djurabekova A.T., Shmirina K.V., Vyazikova N.F., Mamurova M.Н.

Shomurodova Dilnoza Salimovna – PhD, Assistant;

Igamova Saodat Suratovna – Assistant;

Djurabekova Aziza Tahirovna – Professor;

Shmirina Ksenia Vladimirovna - PhD, Assistant;

Vyazikova Natalia Fedorovna - PhD, Assistant;

Mamurova Mavluda Нamzayevna – PhD, Assistant,

DEPARTMENT OF NEUROLOGY AND NEUROSURGERY,

SAMARKAND STATE MEDICAL INSTITUTE,

SAMARKAND, REPUBLIC OF UZBEKISTAN

Abstract: we examined 70 pregnant women who were hospitalized in the maternity ward 1-Clinic SamSMI, as well as in the regional perinatal center in the period from 2008 to 2019. The criteria for the inclusion of patients in the study were: in the main group - pregnant women with preeclampsia and in the comparison group - pregnant women with a physiological course of pregnancy in the late period. There is a strong correlation between the manifestations of clinical and neurological changes, as well as laboratory and biochemical parameters (FW, ADMA) and the data of functional diagnostic methods (EEG, Ultrasound investigation of BCV). In turn, these findings help us to identify the risk group in pregnant women with mild preeclampsia for a possible transition to severe preeclampsia, as well as selection of pregnant women among this cohort for possible development of cerebrovascular pathology during pregnancy, childbirth, and the postpartum period. Which makes it possible to select the correct management of pregnancy and childbirth, and thus the treatment, as well as the prevention of cerebrovascular disease in the future.

Keywords: preeclampsia, pregnant women, endothelial dysfunction, von Willebrand factor.

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Shomurodova D.S., Igamova S.S., Djurabekova A.T., Shmirina K.V., Vyazikova N.F., Mamurova M.Н. ENDOTHELIAL DYSFUNCTION FACTOR AS AN INDICATOR OF CLINICAL AND NEUROLOGICAL DISORDERS IN PREGNANT WOMEN WITH PREECLAMPSIA // Достижения науки и образования № 11(52), 2019 - С.{ см. журнал}.